Featured Articles - October 18, 2021
Type II collagen-positive embryonic progenitors are the major contributors to spine and intervertebral disc development and repair
Xinhua Li, et al., STEM CELLS Translational Medicine
Some studies have reported that type II collagen positive (Col2+) cells encompass early mesenchymal progenitors that continue to become chondrocytes, osteoblasts, stromal cells, and adipocytes in long bone. However, few studies have reported the function and distribution of Col2+ cells in mouse spine and intervertebral disc disease (IVDD). The present study provides the first evidence that Col2+ progenitors are the major source for spine development and the maintenance of spine pattern and IVD and that Col2+ inter annual fibrosis progenitors are essential contributors to IVD repair in IVD injury mouse model. Thus, our findings provide new insights into the spine or IVD development and new therapeutic strategies for IVDD repair and regeneration.
SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells
Ivo Djidrovski, et al., STEM CELLS
Demonstration of the ability of SARS-CoV-2 to infect an airway construct generated from induced pluripotent stem cells is significant since it paves the way for broader studies of viral airway infection using a system that can be manufactured reproducibly.
Findings support for the pivotal importance of Notch signaling in the crosstalk between dental MSC-like perivascular cells and their niches in tissue homeostasis and regeneration
Direct reprogramming platform represents a new model for investigating neuronal maturation and screening neuronal maturation modifiers for the treatment of Huntington's disease patients
High glucose levels epigenetically prime HSCs and macrophages to support the persistence of diabetes-related macrovascular complications
Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.