Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.
Featured Articles - September 28, 2020
Amniotic MSCs reduce pulmonary fibrosis by hampering lung B‐cell recruitment, retention, and maturation
Anna Cargnoni, et al., STEM CELLS Translational Medicine
The immunomodulatory features of amniotic cells can create a microenvironment able to limit the evolution of chronic inflammation to fibrosis. However, the immune modulation induced by amniotic mesenchymal stromal cells (hAMSCs) in models of fibrosis has yet to be elucidated. For the first time, this study shows that in bleomycin‐challenged mice, hAMSCs control pulmonary B‐cell recruitment, retention, maturation, and reduce the formation and expansion of lung lymphoid aggregates. By modulating B‐cell response, hAMSCs hamper the self‐maintaining inflammatory condition promoted by B cells in injured lungs and may contribute to limiting the chronicization of lung inflammation that evolves into the fibrotic lesion.
Galectin‐3 diminishes Wnt signaling in the postnatal subventricular zone
Osama Al‐Dalahmah, et al., STEM CELLS
Galectin‐3 (Gal‐3) is frequently increased in cancer and injury. It regulates inflammation and subventricular zone (SVZ) neurogenesis, yet the signaling pathways whereby it does so are poorly understood. Gal‐3 increases Wnt signaling in cancer cells, but this study shows that it binds to β‐catenin in SVZ cells and negatively regulates Wnt signaling. Gal‐3 also decreased proliferation and increased cell cycle exit. Gal‐3 decreased Wnt signaling in the same cells with increased bone morphogenetic protein signaling. Since Gal‐3 is druggable, these studies suggest Gal‐3 modulators could be used to manipulate Wnt signaling in the clinical setting.
An optimized protocol employing a vertical‐wheel bioreactor achieves the rapid generation of clinically-relevant numbers of human induced pluripotent stem cells
The neurotransmitter norepinephrine functions as a regulator of adult neural progenitor cell proliferation within the periventricular regions of the adult mouse brain
The modulation of B cell responses by mesenchymal stem cell therapy can blunt inflammatory responses in the lung and reduce progression to fibrosis