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Brief reviews of recently published articles, organized by stem cell type.

November 5, 2012 |

“Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein”

Previous attempts to differentiate human pluripotent cells into lung epithelia have generated mixed results; studies in human embryonic stem cells (hESCs) have produced cells that express distal airway epithelial phenotypes at low efficiency (Van Haute et al...

November 5, 2012 | Pluripotent Stem Cells

“Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein”

Previous attempts to differentiate human pluripotent cells into lung epithelia have generated mixed results; studies in human embryonic stem cells (hESCs) have produced cells that express distal airway epithelial phenotypes at low efficiency (Van Haute et al...

October 22, 2012 | Direct Reprogramming

Findings published on October 4th 2012 in Cell Stem Cell, have shown it is possible to reprogramme mouse and human pericytes, brain cells typically found surrounding the endothelial cells of the brain’s capillary network, into neurons. The results from Benedikt Berninger’s group at the Ludwig-Maximilians University Munich could have potential therapeutic implications for patients with...

October 22, 2012 | Pluripotent Stem Cells

Original article from STEM CELLS

“Regulation and Expression of the ATP-Binding Cassette Transporter ABCG2 in Human Embryonic Stem Cells”

ATP-binding cassette sub-family G member 2 (ABCG2) is known to function as a multidrug efflux pump and plays a role in resistance to chemotherapeutic agents in cancer cells. While it has been implicated...

October 22, 2012 | Ependymal Stem Cells

Original article from STEM CELLS

“FM19G11 Favors Spinal Cord Injury Regeneration and Stem Cell Self-Renewal by Mitochondrial Uncoupling and Glucose Metabolism Induction”

Activation of resident adult stem/progenitor cells for the treatment of some disease/injury states is often seen as a viable alternative to the transplantation of...

October 22, 2012 | Skin Stem Cells

Original article from STEM CELLS

“Skin-derived Precursors as a Source of Progenitors for Cutaneous Nerve Regeneration”

Studies have taught us that while peripheral cutaneous nerves have an amazing regenerative capability in response to damage (Navarro et al), numerous human diseases are associated with incomplete nerve...

October 12, 2012 | Adipose Stem Cells

Original article from STEM CELLS Translational Medicine

“An Abundant Perivascular Source of Stem Cells for Bone Tissue Engineering”

The isolation of mesenchymal stem cell (MSC)-like cells for bone formation/regeneration currently relies on their ability to adhere to culture plates and their extended growth in vitro, which...

October 12, 2012 | Pluripotent Stem Cells

Original article from STEM CELLS Translational Medicine

“Variability in the Generation of Induced Pluripotent Stem Cells - Importance for Disease Modeling”

One of the most interesting uses of induced pluripotent stem cells (iPSCs), alongside potential immunologically matched cell replacement therapy, is the modelling of complex human diseases (Vitale...

October 12, 2012 | Neural Stem Cells

Original article from STEM CELLS Translational Medicine

“Neural Stem Cell Grafting Counteracts Hippocampal Injury-Mediated Impairments in Mood, Memory, and Neurogenesis”

Injury to the hippocampus, an organ vital for cognitive and mood function (Deng et al and Samuels and Hen), is understood to lead to increased neurogenesis from...

October 8, 2012 |

“Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–Like Cells in Mice”

A report from a team of researchers at Kyoto University published online in Science, and reported widely (see further reading), has demonstrated the ability of primordial germ cell-like cells (PGCLCs) derived from mouse embryonic stem cells (mESCs) and induced pluripotent stem cells (iPSCs) to produce...

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