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New Strategies in Tissue Engineering and Regenerative Medicine



Stem cells are a powerful resource for producing a variety of cell types to be used in translational medicine. Translational medicine represents a new era in medicine by "translating" basic biological research into biomedical applications aimed to improve health outcomes of patients with a variety of chronic diseases that lack clinically effective therapies. This constantly evolving field draws from the strengths of multidisciplinary approaches including biology, chemistry, physics, bioengineering, and material science to develop novel approaches for stem cell therapy and tissue regeneration. The exponential growth in research studies covering regenerative medicine has given rise to cell-based treatments for regeneration of skin, nerve, cartilage, cardiac, and other critical organ tissues. This virtual collection provides original research and literature reviews that contribute to the fields of tissue engineering and regenerative medicine by reporting on new strategies with the potential to be fully realized for the treatment of tissues and damaged organs.

Editor's Note

by Terry R.J. Lappin, Concise Review Editor of STEM CELLS and STEM CELLS Translational Medicine.

Concise Review: New Frontiers in MicroRNA-Based Tissue Regeneration
Jessica E. Frith, Enzo R. Porrello, Justin J. Cooper-White
Stem Cells Trans Med 2014; 3:969-976; first published on May 29, 2014; doi:10.5966/sctm.2014-0032

Xiphoid Process-Derived Chondrocytes: A Novel Cell Source for Elastic Cartilage Regeneration
Seungwoo Nam, Wheemoon Cho, Hyunji Cho, Jungsun Lee, EunAh Lee, Youngsook Son
Stem Cells Trans Med 2014; 3:1381-1391; first published on September 9, 2014; doi:10.5966/sctm.2014-0070

Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment
Mathieu Blais, Rémi Parenteau-Bareil, Sébastien Cadau, François Berthod
Stem Cells Trans Med 2013; 2:545-551; first published on June 3, 2013; doi:10.5966/sctm.2012-0181

Intra-Articular Injection of Human Meniscus Stem/Progenitor Cells Promotes Meniscus Regeneration and Ameliorates Osteoarthritis Through Stromal Cell-Derived Factor-1/CXCR4-Mediated Homing
Weiliang Shen, Jialin Chen, Ting Zhu, Longkun Chen, Wei Zhang, Zhi Fang, Boon Chin Heng, Zi Yin, Xiao Chen, Junfeng Ji, Weishan Chen, Hong-Wei Ouyang
Stem Cells Trans Med 2014; 3:387-394; first published on January 21, 2014; doi:10.5966/sctm.2012-0170

1α,25-Dihydroxyvitamin D3 Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration
Noriyuki Aoi, Keita Inoue, Toshihiro Chikanishi, Ryoji Fujiki, Hanako Yamamoto, Harunosuke Kato, Hitomi Eto, Kentaro Doi, Satoshi Itami, Shigeaki Kato, Kotaro Yoshimura
Stem Cells Trans Med 2012; 1:615-626; first published on July 27, 2012; doi:10.5966/sctm.2012-0032

Concise Review: Mesenchymal Stromal Cells Used for Periodontal Regeneration: A Systematic Review
Paul Monsarrat, Jean-Noël Vergnes, Cathy Nabet, Michel Sixou, Malcolm L. Snead, Valérie Planat-Bénard, Louis Casteilla, Philippe Kémoun
Stem Cells Trans Med 2014; 3:768-774; first published on April 17, 2014; doi:10.5966/sctm.2013-0183

A Novel Combinatorial Therapy With Pulp Stem Cells and Granulocyte Colony-Stimulating Factor for Total Pulp Regeneration
Koichiro Iohara, Masashi Murakami, Norio Takeuchi, Yohei Osako, Masataka Ito, Ryo Ishizaka, Shinji Utunomiya, Hiroshi Nakamura, Kenji Matsushita, Misako Nakashima
Stem Cells Trans Med 2013; 2:521-533; first published on June 12, 2013; doi:10.5966/sctm.2012-0132

Safety and Feasibility for Pediatric Cardiac Regeneration Using Epicardial Delivery of Autologous Umbilical Cord Blood-Derived Mononuclear Cells Established in a Porcine Model System
Susana Cantero Peral, Harold M. Burkhart, Saji Oommen, Satsuki Yamada, Scott L. Nyberg, Xing Li, Patrick W. O'Leary, Andre Terzic, Bryan C. Cannon, Timothy J. Nelson, Wanek Program Porcine Pipeline Group
Stem Cells Trans Med 2015; 4:195-206; first published on January 5, 2015; doi:10.5966/sctm.2014-0195

Concise Review: Heart Regeneration and the Role of Cardiac Stem Cells
Stefan Koudstaal, Sanne J. Jansen of Lorkeers, Roberto Gaetani, Johannes M.I.H. Gho, Frebus J. van Slochteren, Joost P.G. Sluijter, Pieter A. Doevendans, Georgina M. Ellison, Steven A.J. Chamuleau
Stem Cells Trans Med 2013; 2:434-443; first published on May 8, 2013; doi:10.5966/sctm.2013-0001

Concise Review: Unraveling Stem Cell Cocultures in Regenerative Medicine: Which Cell Interactions Steer Cartilage Regeneration and How?
Tommy S. de Windt, Jeanine A.A. Hendriks, Xing Zhao, Lucienne A. Vonk, Laura B. Creemers, Wouter J.A. Dhert, Mark A. Randolph, Daniel B.F. Saris
Stem Cells Trans Med 2014; 3:723-733; first published on April 24, 2014; doi:10.5966/sctm.2013-0207

Concise Review: Microfluidic Technology Platforms: Poised to Accelerate Development and Translation of Stem Cell-Derived Therapies
Drew M. Titmarsh, Huaying Chen, Nick R. Glass, Justin J. Cooper-White
Stem Cells Trans Med 2014; 3:81-90; first published on December 5, 2013; doi:10.5966/sctm.2013-0118

Reliable Generation of Induced Pluripotent Stem Cells From Human Lymphoblastoid Cell Lines
Robert Barrett, Loren Ornelas, Nicole Yeager, Berhan Mandefro, Anais Sahabian, Lindsay Lenaeus, Stephan R. Targan, Clive N. Svendsen, Dhruv Sareen
Stem Cells Trans Med 2014; 3:1429-1434; first published on October 8, 2014; doi:10.5966/sctm.2014-0121