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Vitamin C effective in targeting cancer stem cells



Vitamin C is up to 10 times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK.

The research, published in Oncotarget, is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fueling fatal tumors.

Michael P. Lisanti, M.D., Ph.D., professor of translational medicine at the University of Salford, said, “We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C. Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step.”

Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumor recurrence and metastasis (regrowth).

The Salford team set out to assess the bioenergetics of cancer stem cells – the processes that allow the cells to live and thrive – with a view to disrupting their metabolism. Focusing on energy transfer, they measured the impact on cell lines in a laboratory of seven substances, the clinically approved drug stiripentol, three natural products  – caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid – and experimental pharmaceuticals such as actinonin, FK866 and 2-DG.

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C outperforming 2-DG by tenfold in terms of potency.

Vitamin C has previously been shown to be effective as a non-toxic anti-cancer agent in studies by Nobel Prize winner Linus Pauling and was recently shown to reduce mortality by 25 percent on breast cancer patients in Japan. However, its effects on CSC activity have not been previously evaluated and in this context it behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the “powerhouse” of the cell.

According to Gloria Bonuccelli, Ph.D., lead author and another member of the Salford team, “This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer. Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumor recurrence, further disease progression and metastasis.”

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DOI: 10.18632/oncotarget.15400