Researchers at MIT and Brigham and Women’s Hospital have shown that they can grow unlimited quantities of intestinal stem cells, then stimulate them to develop into nearly pure populations of different types of mature intestinal cells.
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Coverage of the latest news and updates from the field of stem cells.
Scientists from the New York Stem Cell Foundation (NYSCF) Research Institute and Columbia University Medical Center (CUMC), both in New York City, have used stem cells created from the skin of patients with a rare form of diabetes to elucidate an important biochemical pathway for beta-cell failur
Scientists have been working for years to use the ability of stem cells to make multiple kinds of specialized cells and repair injuries throughout the body. But causing specialized adult cells to revert to stem cells and work on repairs has been challenging.
Using the technique, scientists were able to grow a pure, self-renewing population of stem cells specific to the human foregut, which is the upper section of the human digestive system. These cells could then be developed further to produce liver or pancreatic cells.
"We are excited to begin the next phase of this neural stem cell trial, further evaluating safety precautions while increasing both the number of injections and cells transplanted in ALS patients," says Jonathan Glass, M.D., director of the Emory ALS Center and principal investigator of the Emory
“If you think of a cell as a drug factory, what we’re doing is targeting cell-based drug factories to damaged or diseased tissues where the cells can produce drugs at high enough levels to have a therapeutic effect,” said Jeffrey Karp, Ph.D.
The research, by scientists at The Institute of Cancer Research (ICR), London, provides the latest evidence that despite having identical DNA, sister stem cells can display considerable differences in their molecular characteristics.
The Institute for Regenerative Medicine at Wake Forest University School of Medicine (Wake Forest Baptist Medical Center) has been selected to lead the second phase of the Armed Forces Institute of Regenerative Medicine (AFIRM).
The results, which are reported online Sept. 17 in The EMBO Journal, could eventually lead to ways to repair damaged insulin-producing beta cells or pancreatic duct cells.
The finding, which involves a mysterious protein called MBD3, might help facilitate the production of stem cells for medical use as well as advance our understanding of the process by which adult cells can revert back into their embryonic state.