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What’s the Stem Cells Buzz this Week? - QC for iPSCs, Brain MPCs and MS, EV Therapy to Counter Stroke, and, Wound Healing with Amnion Membrane Hydrogel!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Quality Control for iPSCs!

Therapeutic applications for human induced pluripotent stem cells (hiPSC) require a means of first assessing hiPSC quality. Researchers from the lab of Timothy J. Nelson (Mayo Clinic, Minnesota, USA) have now designed a novel means to assess hiPSC quality based on hypersensitivity to the topoisomerase inhibitor etoposide. This new STEM CELLS Translational Medicine article describes how the etoposide sensitivity assay (ESA) provides a simple, straightforward method to establish hiPSC quality and function by quantifying the amount of etoposide required to kill treated cells and comparing that value to a standard value associated with high-quality clones.

Changes in Brain MPCs Associate with MS Pathology

The development of multiple sclerosis (MS) correlates with changes to the stem cell containing vasculature. The team of Ellen Iacobaeus (Karolinska Institutet, Stockholm, Sweden) now describes the presence of mesenchymal perivascular cells (MPCs) in human brain vasculature and show that phenotypic changes to these cells during MS progression associate with inflammation, demyelination, and disease duration. The authors suggest that these data support vessel-targeted therapeutic strategies for patients with progressive MS. See STEM CELLS Translational Medicine for all the details.


EV Therapy to Counter Stroke

A new review article from Thorsten R. Doeppner (University Medical Center Göttingen, Germany) and Bernd Giebel (University of Duisburg-Essen Medical School, Essen, Germany) seeks to highlight some of the recent advances in the field of stem cell-derived extracellular vesicles (EVs) as a therapeutic means to treat stroke. Excitingly, the application of EVs in preclinical stroke studies suggests a better therapeutic response than treatment with stem cells themselves! Read all about it in STEM CELLS Translational Medicine!

Wound Healing with Amnion Membrane Hydrogel

The application of amniotic membrane represents an effective means to promote wound healing, although handling and cost difficulties have limited its use. Now, new research from Sean V. Murphy and Anthony Atala (Wake Forest School of Medicine, North Carolina, USA) describe the development of an easy to produce and apply solubilized amnion membrane-hyaluronic acid (HA) hydrogel (HA-SAM). Exactingly, this new product functions well in wound treatment/dressing and also overcomes many of the limitations associated with employing fresh, cryopreserved, or dehydrated tissue. For all the fine print, head on over to STEM CELLS Translational Medicine now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!