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What’s the Stem Cells Buzz this Week? - Hematopoietic Regulation and Regeneration, Restoration of Dysfunctional Endothelial Progenitor Cells, and the Production of Mature Heart Muscle!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Reviewing the Epigenetic Regulation of Hematopoiesis

The title for this Stem Cells Buzz article says it all! Straight out of the lab of Annarita Miccio (Imagine Institute, Paris, France) comes a summary of recent epigenetic and genetic studies in hematopoietic cells that have provided fresh insight into human hematopoiesis and have stimulated the construction of novel therapeutic approaches. For all the details on this new article from Antoniani et al., scoot on over to STEM CELLS Translational Medicine!

PPARα Microparticles Reprogram Dysfunctional Bone Marrow EPCs

Patients suffering from various metabolic pathologies present with a compromised vascular system caused partly by dysfunctional bone marrow-derived endothelial progenitor cells (EPCs). Now, a team of researchers from lab of Maria Carmen Martinez (Université Angers, France) has reprogrammed EPCs via small membrane vesicles known as microparticles (MPs) carrying the peroxisome proliferator-activated receptor (PPARα), which promotes EPC maturation and myeloid lineage differentiation. While EPCs from mice fed on a high-fat diet displayed reduced levels of circulating EPCs and impaired EPC and monocytic progenitor cell differentiation, treatment with MPs carrying PPARα restored the lost differentiation capacity and enhanced in vivoangiogenesis. See STEM CELLS Translational Medicine now for all the details.

Synergistically Regenerating Hematopoiesis

To boost hematopoietic regeneration following chemotherapy, researchers from the lab of Phuong L. Doan (Duke University, Durham, NC, USA) sought out a synergistic solution. In their new STEM CELLS study, Piryani et al. demonstrated that co-treatment with the epidermal growth factor (EGF) hematopoietic growth factor and granulocyte colony-stimulating factor (G-CSF) efficiently accelerated hematopoietic regeneration. Their study also indicated that EGF upregulated the receptor for G‐CSF (G‐CSFR), and so this new combination could represent an effective means to treat chemotherapy‐induced myelosuppression.

A Little Stretch Induces Engineered Heart Muscle Function

While the efficiency of cardiomyocytes differentiated from human pluripotent stem cells (hPSCs) keeps on rising with each study, the problem of functional immaturity remains. New research from Joseph C. Wu and Oscar J. Abilez (Stanford University, Stanford, CA, USA) employed computational modeling to test the effects of “passive stretch” on hPSC-derived heart tissue maturation. Excitingly, a little stretching significantly affected structural and functional maturation and, therefore, may represent an essential step towards the clinical application of functional engineered heart tissues. Stretch your legs (or fingers?) and head over to STEM CELLS to read more!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!