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What’s the Stem Cells Buzz this Week? – A Novel DPPA4 Cofactor, Stem Cell Protection, Stem Cell Myocardial Repair, and the Fate of MSCs!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Novel DPPA4 Cofactor in Human Pluripotent Cells Discovered

New research from the laboratory of Paul S. Knoepfler (University of California, Davis, USA) has described a novel cofactor for the Developmental Pluripotency-Associated-4 (DPPA4) core pluripotency protein. Somanath et al. demonstrate that DPPA4 interacts with ERBB3‐related signaling molecule EBP1, a protein not previously associated with pluripotency. See STEM CELLS now for all the details.

Melatonin Nanoparticles Protect Stem Cells

In a new STEM CELLS study from the lab of Yundai Chen (Chinese PLA General Hospital, Beijing, China), researchers have described an interesting new way to boost stem cell transplantation in ischemic heart tissue. Ma et al. dsicovered that melatonin encapsulated in poly (lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) (PLGA-mPEG) nanoparticles enhanced survival of adipose-derived mesenchymal stem cells (MSCs) in vitro and in vivo and this may represent a promising strategy for myocardial infarction therapy.

Reviewing Strategies for Stem Cell Myocardial Repair

Recent years have seen huge strides towards stem cell-based therapy as a strategy for cardiac repair/regeneration and functional recovery in ischemic heart disease patients. In recognition of this fact, researchers from the labs of Jian'an Wang and Xinyang Hu (Zhejiang University/Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China) now appraise preclinical and clinical findings, discuss the underlying mechanisms of stem cells, and critically review different optimized strategies for stem cell-based therapy with their clinical translatability and potential limitations. See STEM CELLS now for a fascinating read.

The Fate of MSC Post Infusion

While mesenchymal stem cells (MSCs) exhibit potent immunomodulatory capacities, we lack sufficient understanding of the mechanisms at play during the short time between intravenous infusion and entrapment and death in the lungs. Now, researchers from the lab of Martin J. Hoogduijn (Erasmus MC, Rotterdam, Netherlands) have discovered that the monocytes of the innate immune system determine the effect of MSCs by rapidly mediating, distributing, and transferring their influence to distant body sites. See STEM CELLS now to read more on this important new study.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!