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What’s the Stem Cells Buzz this Week? - Spinal Cord Injury Repair, Cancer Stem Cells, NSC Store‐operated Channels, and Reprogramming with Wnt!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Co‐Transplantation of ASCs and OECs for SCI Repair

The application of adipose tissue-derived stem cells (ASCs) or olfactory ensheathing cells (OECs) has shown promise in different models of spinal cord injury (SCI). Now, research from the laboratory of António J. Salgado (University of Minho, Braga, Portugal) studying dorsal root ganglia explants suggests that while ASCs and OECs induce neurite outgrowth through distinct mechanisms, co‐transplantation of cells into a rat model of SCI induced functional improvements and a reduction in inflammatory cell infiltration to the injury site. For more on this promising duo, see STEM CELLS now.

Cancer Stem Cells and Treatment Resistance

A new review article from Romano Danesi (University of Pisa, Italy) aims to lay out the role of cancer stem cells (CSCs) in the development of resistance to tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Additionally, this timely review also discusses the implications of this phenomenon for the management of patients. For a great read, look no further than STEM CELLS.

SOC and Neural Stem Cells

A new study from the laboratory of Valérie Coronas (University of Poitiers, France) sought to explore the relevance of store-operated calcium channels (SOC) and calcium signaling in neural stem cells (NSCs), given the high expression of calcium signaling-related transcripts. Their new STEM CELLS study now demonstrates that NSCs express SOC that support calcium entries, and that pharmacological inhibition of SOC entries decreases proliferation and self‐renewal of NSC by promoting asymmetric at the expense of symmetric proliferative division.


Wnt pathway in Human Cell Reprogramming

During the reprogramming process, a somatic cell passes through an initiation (mesenchymal-to-epithelial transition) and a maturation (acquisition of pluripotency) phase. New research from the lab of Karlen Gazarian (Universidad Nacional Autónoma de México/Ciudad Universitaria, Mexico) now suggests that these phases display a differential response to Wnt signaling activation. Cevallos et al. demonstrate that Wnt signaling enhances the initiation phase, but is detrimental to the maturation phase, as continued signaling activates mesendodermal differentiation. See STEM CELLS now for all the details.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!