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Stem cells seem to work in fighting obesity in mice – but what about humans?

Obesity is an increasing global health problem associated with several comorbidities and a high risk of mortality. A wide spectrum of interventions has been proposed for weight management in clinical settings, but most are effective only in the short term, since it is common for patients with obesity to gradually regain the weight lost. This unfavorable outcome continues to stimulate researchers to search for an effective long-lasting treatment for obesity.

Scientists solve case of the missing subplate, with wide implications for brain science

The disappearance of an entire brain region should be cause for concern. Yet, for decades scientists have calmly maintained that one brain area, the subplate, simply vanishes during the course of human development.

Recently, however, research has revealed genetic similarities between cells in the subplate and neurons implicated in autism — leading a team of scientists to wonder: What if subplate cells don’t actually vanish at all?

Exercise makes blood of obese people healthier

Exercise can reduce inflammation in obese people by changing the characteristics of their blood, according to new research published in The Journal of Physiology.

Hematopoietic Stem Cell Sorting: Keeping it Simple with a CD11a and EPCR Combination

A simple combination of two markers may provide a quick and easy means to sort mouse hematopoietic stem cell from blood samples

Periodontal Ligament Stem Cells - A New and Effective means to Treat Optic Nerve Injury?

Treatment with human periodontal ligament stem cells in a rat model of optic nerve injury leads to enhanced retinal ganglion cell survival and axon regeneration

Scientists capture elusive cell that can regenerate an entire flatworm

Researchers have captured the one cell that is capable of regenerating an entire organism. For over a century, scientists have witnessed the effects of this cellular marvel, which enables creatures such as the planarian flatworm to perform death-defying feats like re-growing a severed head. But until recently, they lacked the tools necessary to target and track this cell, so they could watch it in action and discover its secrets.

Repair and regeneration of peripheral nerves possible with dual polymer hydrogel adhesive

Researchers have demonstrated that a novel biocompatible adhesive made of two naturally derived polymers is 15 times stronger than adhesive materials currently used for nerve reconstruction and can support the survival, extension and proliferation of cells essential for nerve regeneration. The study showing the regenerative potential of this new hydrogel adhesive in vitro and when implanted in a mouse model of suture-less repair of sciatic nerves is published in Tissue Engineering, Part A.

Induced Mesenchymal Stem Cells: A Promising New Treatment Strategy for Inflammatory Bowel Disease?

New research suggests that MSCs derived from induced pluripotent stem cells are as effective as adipose-derived MSCs in treating inflammatory bowel disease in mice

Small Molecules boost Cpf1-mediated Genome Editing in Pluripotent Stem Cells

Chinese researchers discover of two small molecule compounds that enhance CRISPR-Cpf1-based genome engineering of human pluripotent stem cells

Cell umbrella protects stem cells from DNA damage

Tissue-specific stem cells have the crucial role of maintaining and replenishing all the specialized cells that make up a given tissue or system, so it is essential that their functions are preserved throughout an organism’s life. These adult stem cells therefore reside in dedicated microenvironments called stem cell niches, which help to regulate and protect the stem cells.


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