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Fluorescent Molecules Reveal how Cancer Stem Cells are Selectively Inhibited

A team of researchers at Lund University in Sweden has developed a fluorescent variant of a molecule that inhibits cancer stem cells. Capturing images of when the molecule enters a cell has enabled the researchers, using cell-biological methods, to successfully describe how and where the molecule counteracts the cancer stem cells.

Side Image, Cells.

New Insight Into How Autism Might Develop in Human Brain

A McGill University team of scientists led by Carl Ernst, Ph.D., at the Douglas Hospital Research Centre, revealed a molecular mechanism that may play a role in the development of autism.

By taking skin cells from patients and reprogramming those cells to become brain cells through genetic engineering, Dr. Ernst along with graduate student Scott Bell and Edward A. Fon, M.D., and Thomas M. Durcan, Ph.D., colleagues at the Montreal Neurological Institute and Hospital, tracked how a brain cell with the patient’s own mutation develops improperly.

What’s the Stem Cells Buzz this Week? - Proteoglycan Morphogenetic Markers, ESC PTM Regulation by LRRN1, Runx1-mediated Cell Proliferation, and Preconditioned MSCs for Bone Repair!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Enhancing Stem Cells With Oxygen and Forming Them Into Spheroids Leads to Better Bone Repair

 

DURHAM, N.C. JULY, 2018

Depriving stem cells of oxygen and forming them into spheroids before using them to treat bone defects increases their ability to form new bone and repair existing bone, according to a new study in STEM CELLS.

Researchers identify novel function of spermatogonial stem cells’ self-renewal factor

Researchers have discovered a novel function of fibroblast growth factor 2 (FGF2), a self-renewal factor for spermatogonial stem cell (SSC), which is the origin of sperm production.

Side Image. FGF2 expands RARG expressing subset of SSCs FGF2 facilitates RA action toward proper spermatogenesis.

Stem cells seem to work in fighting obesity in mice – but what about humans?

Obesity is an increasing global health problem associated with several comorbidities and a high risk of mortality. A wide spectrum of interventions has been proposed for weight management in clinical settings, but most are effective only in the short term, since it is common for patients with obesity to gradually regain the weight lost. This unfavorable outcome continues to stimulate researchers to search for an effective long-lasting treatment for obesity.

Scientists solve case of the missing subplate, with wide implications for brain science

The disappearance of an entire brain region should be cause for concern. Yet, for decades scientists have calmly maintained that one brain area, the subplate, simply vanishes during the course of human development.

Recently, however, research has revealed genetic similarities between cells in the subplate and neurons implicated in autism — leading a team of scientists to wonder: What if subplate cells don’t actually vanish at all?

Exercise makes blood of obese people healthier

Exercise can reduce inflammation in obese people by changing the characteristics of their blood, according to new research published in The Journal of Physiology.

Hematopoietic Stem Cell Sorting: Keeping it Simple with a CD11a and EPCR Combination

A simple combination of two markers may provide a quick and easy means to sort mouse hematopoietic stem cell from blood samples

Periodontal Ligament Stem Cells - A New and Effective means to Treat Optic Nerve Injury?

Treatment with human periodontal ligament stem cells in a rat model of optic nerve injury leads to enhanced retinal ganglion cell survival and axon regeneration

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