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Scientists capture elusive cell that can regenerate an entire flatworm

Researchers have captured the one cell that is capable of regenerating an entire organism. For over a century, scientists have witnessed the effects of this cellular marvel, which enables creatures such as the planarian flatworm to perform death-defying feats like re-growing a severed head. But until recently, they lacked the tools necessary to target and track this cell, so they could watch it in action and discover its secrets.

Repair and regeneration of peripheral nerves possible with dual polymer hydrogel adhesive

Researchers have demonstrated that a novel biocompatible adhesive made of two naturally derived polymers is 15 times stronger than adhesive materials currently used for nerve reconstruction and can support the survival, extension and proliferation of cells essential for nerve regeneration. The study showing the regenerative potential of this new hydrogel adhesive in vitro and when implanted in a mouse model of suture-less repair of sciatic nerves is published in Tissue Engineering, Part A.

Induced Mesenchymal Stem Cells: A Promising New Treatment Strategy for Inflammatory Bowel Disease?

New research suggests that MSCs derived from induced pluripotent stem cells are as effective as adipose-derived MSCs in treating inflammatory bowel disease in mice

Small Molecules boost Cpf1-mediated Genome Editing in Pluripotent Stem Cells

Chinese researchers discover of two small molecule compounds that enhance CRISPR-Cpf1-based genome engineering of human pluripotent stem cells

Cell umbrella protects stem cells from DNA damage

Tissue-specific stem cells have the crucial role of maintaining and replenishing all the specialized cells that make up a given tissue or system, so it is essential that their functions are preserved throughout an organism’s life. These adult stem cells therefore reside in dedicated microenvironments called stem cell niches, which help to regulate and protect the stem cells.

Discovery of new type of stem cell state might ensure constant supply of healthy fat cells

It’s not the amount of fat, but the ability to store fat in the right locations that equates to good metabolic health in humans. In part, for this to occur new fat cells must be made “on demand” when the body has an energy surplus.

Researchers engineer human bone marrow tissue

Researchers have developed an artificial tissue in which human blood stem cells remain functional for a prolonged period of time. Scientists from the University of Basel, University Hospital Basel and ETH Zurich have reported their findings in PNAS.

Stem cell niche for 10 billion colon cells a day

Researchers at the University of Zurich (UZH) have discovered the identity of the stem cell niche of the colon. The niche comprises special cells that activate the stem cells of the adjacent intestinal epithelium and are responsible for its continuous renewal.

Without the activation signal, the epithelium perishes. If it’s constantly activated, early stages of cancer develop. The discovery helps to improve our understanding of intestinal cancer and inflammation.

New study points to a potential “Achilles heel” in brain cancer

Scientists at Virginia Commonwealth University believe they have uncovered an “Achilles heel” of glioblastoma multiforme (GBM), the most common and deadly form of brain cancer. Their study, published in the Proceedings of the National Academy of Sciences, details how a mechanism that protects glioma stem cells can potentially be exploited to develop new and more effective treatments for GBM.

Researchers show stem cells fashion kidney functions based on when they converge

Arriving early or late can have big consequences for early-stage cells that gather to form a new kidney, a team of University of Southern California (USC) researchers discovered.


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