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New Findings on Coronary Artery Formation Could Change how Engineers try to Regrow Them

It’s tempting to think all it takes to regrow arteries lost to heart disease is encouraging the proliferation of new blood vessel cells, but that hasn’t worked out. Now, Stanford biologist Kristy Red-Horse, Ph.D., and colleagues think they’ve figured out part of the problem. As the researchers reported recently week in Nature, the process of turning a group of blood vessel cells into an artery actually requires that they stop growing, and trying to speed up their expansion may actually backfire.

What’s the Stem Cells Buzz this Week? - Astrocytic Gene Hydroxymethylation, Facilitating Cells, Megakaryocyte-induced Myeloproliferation, and a Regenerative Medicine Roadmap!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Mesenchymal Stem Cell-based Combinatorial Treatment Shows Promise for Lung Repair

New research suggests that a combination of MSCs and ATRA treatment in the presence of p70S6k1 signaling can enhance lung repair in a mouse emphysema model

How Short-term Fasting Affects Intestinal Stem Cell Function during Aging

Researchers discover than short-term fasting induces intestinal regenerative effects via increases in fatty acid oxidation in intestinal stem cells

Motor Cortex Targeting Improves Treatment of ALS by Engineered Human Neural Progenitor Cells

Researchers establish that transplantation of growth factor-secreting human NPCs can delay paralysis and extend lifespan in a rat model of ALS

What’s the Stem Cells Buzz this Week? – The Adaptive Mesenchymal Niche, iPSC-derived Retinal Organoids, Blind Mole Rat ASCs, and Splicing in Myeloid Malignancies!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

New Protocol Enables Kidney Disease Modeling for Potential New Therapies

Human stem cells are of great interest in the fields of regenerative medicine and research because they reproduce indefinitely and can differentiate into every other cell type found in the body. While stem cells naturally occur in very few places in the adult body, induced pluripotent stem cells (iPS cells) can be produced directly from adult cells, and offer the potential for a patient to one day have a limitless source of personalized cells to replace those lost to damage or disease.

A mature podocyte, colored purple.

Discovery of Gene That Controls Bone-To-Fat Ratio could lead to new Osteoporosis Treatments

University of California, Los Angeles (UCLA) researchers have found that a gene previously known to control human metabolism also controls the equilibrium of bone and fat in bone marrow as well as how an adult stem cell expresses its final cell type. The findings could lead to a better understanding of the disruption of bone-to-fat ratio in bone marrow as well as its health consequences, and also point to the gene as a promising therapeutic target in the treatment of osteoporosis and skeletal aging.

PGC-1α gene as a critical factor in maintaining bone-fat balance in the bone marrow.

Engineered cancer cells Can fight Primary and Metastatic Cancer

What if cancer cells could be re-engineered to turn against their own kind? A new study led by researchers at Brigham and Women's Hospital, Boston, Mass., leverages the power of gene editing to take a critical step toward using cancer cells to kill cancer.

The team reports promising results in preclinical models across multiple types of cancer cells, establishing a potential roadmap toward clinical translation for treating primary, recurrent and metastatic cancer. Results are published in Science Translational Medicine.

image, cancer cells (green) track primary cancer cells (red) in the brain

Turbulence is Good for the Blood

Blood flows through the body smoothly in order to transport its content throughout the body. In a new study published in Cell, scientists at Kyoto University’s Center for iPS Cell Research and Application (CiRA) show that small levels of turbulence in the blood promotes the generation of platelets, the cells responsible for wound healing.

Using this new information, they report a bioreactor that produces more than 100 billion platelets from iPS cells, a number that can be used to treat patients.

Image of new bioreactor

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