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Most Influential Articles from the Stem Cell Sister Journals



Stem Cells | Stem Cells Translational Medicine

A Note from Terry R.J. Lappin, Concise Review Editor for the Sister Journals

The major challenge confronting regenerative medicine is to find safe practical procedures to harness the potential of stem cells for long term clinical benefit. Two key objectives of the escalating efforts in stem cell research are to develop a deep understanding of stem cell biology, and to apply this knowledge to exploit novel therapeutic options.

STEM CELLS and STEM CELLS Translational Medicine focus on these areas, covering a diverse array of preclinical and clinical research.

The 14 well-cited articles selected for this special issue attest to the depth and breadth of recent publications in the Sister Journals. They report studies on exosomes, mesenchymal stem cells and induced pluripotent stem cells which were designed to clarify mechanisms of differentiation, mechanosensitivity and immunosuppression, using cutting-edge techniques such as lineage tracing and CRISPR/Cas9. These approaches have provided valuable insights into neuroregeneration, angiogenesis, hematopoiesis, cancer progression, aging and wound healing. Practical issues such as the source, stage of development and purity of donor cells and the use of xeno-free media are also discussed.

The Editors hope that you will enjoy browsing this eclectic collection of recent manuscripts from STEM CELLS and STEM CELLS Translational Medicine, and that their continuing commitment to the Sister Journals will make a useful contribution to the ongoing progress of regenerative medicine.

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Tracing the Fate of Limbal Epithelial Progenitor Cells in the Murine Cornea
N. Di Girolamo et al.

Establishing Criteria for Human Mesenchymal Stem Cell Potency
Rebekah M. Samsonraj et al.

HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing
Bin Zhang et al.

Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus
Gunes Uzer et al.

Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells
Takayuki Nakagomi et al.

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity
Jenna M. Frame et al.

LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway
Mingli Zhou et al.


Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4/beta-Catenin Pathway
Bin Zhang et al.

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
Thorsten R. Doeppner et al.

Transplantation of Induced Pluripotent Stem Cell-Derived Neural Stem Cells Mediate Functional Recovery Following Thoracic Spinal Cord Injury Through Remyelination of Axons
Ryan P. Salewski et al.

Defined Culture of Human Embryonic Stem Cells and Xeno-Free Derivation of Retinal Pigmented Epithelial Cells on a Novel, Synthetic Substrate
Britney O. Pennington et al.

High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells
Daman Kumari et al.

Naïve Induced Pluripotent Stem Cells Generated From β-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9
Yuanyuan Yang et al.

Concise Review: Review and Perspective of Cell Dosage and Routes of Administration From Preclinical and Clinical Studies of Stem Cell Therapy for Heart Disease
Samuel Golpanian et al.