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CSC Targeting in Breast Cancer

Specifically targeting breast cancer stem cells (CSC) represents a potentially effective approach to the prevention of metastasis and local recurrence of HER2‐positive breast cancer after trastuzumab treatment. A new STEM CELLS review article from Yan Qiu and Xiaobo Luo (Sichuan University, Chengdu, China) now discusses the mechanism of trastuzumab resistance in CSCs associated with HER2‐positive breast cancer and the approaches that may reduce or eradicate CSCs after anti‐HER2 therapy.