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ERβ Signaling Reduces GSC Stemness

The elimination of glioma stem cells (GSCs) represents a therapeutic approach to the treatment of glioblastoma. A new STEM CELLS study from the lab of Gangadhara R. Sareddy (University of Texas Health San Antonio, USA) reports that estrogen receptor β (ERβ) activation or upregulation reduced the viability and self‐renewal of GSCs and increased apoptosis by reducing glutamate receptor signaling. ERβ signaling prompted the inhibition of tumor progression and improved survival in orthotopic murine models, thereby suggesting ERβ agonists as promising therapeutic agents in glioblastoma patients.