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EYA1 Regulates GSC Maintenance and Proliferation

A recent STEM CELLS article from researchers led by James K. C. Liu (H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL) and Jeremy N. Rich (UC San Diego, La Jolla, CA, USA) identifies a role for EYA1 (Eyes Absent 1), a transcriptional co‐activator and tyrosine phosphatase, in the proliferation and migration of glioma stem cells (GSCs) through the regulation of MYC. Kim et al. identified EYA1 using an in silico analysis of a GSC-specific targeting peptide isolated through a combination of in vitro and in vivo phage display biopanning strategies. Overall, this exciting new study demonstrates how peptides isolated from phage display biopanning may allow for the identification of novel cell-specific markers, which may be used for further cellular characterization and therapeutic targeting.