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How MSC-EVs Influence Angiogenesis and Chondrogenesis

Mesenchymal stem cells (MSCs) represent an exciting source for regenerative medicine applications. MSCs derived from different tissues might have distinctive characteristics, while related studies suggest a critical therapeutic role for extracellular vesicles secreted by MSCs. In a recent STEM CELLS Translational Medicine article, researchers led by Roberta Tasso and Chiara Gentili (University of Genova, Genoa, Italy) compared extracellular vesicles isolated from bone marrow and adipose tissue MSCs. Gorgun et al. observed different functional effects of MSC-derived exosomes on the differentiation and maturation of cartilage tissue and angiogenesis; therefore, a deeper investigation of biological effects may aid the specific selection of optimal extracellular vesicle-cell sources for use in specific therapeutic settings.