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Immunogenicity Of iPSC-derived Myogenic Cells

The immunogenicity of human induced pluripotent stem cell (iPSC)‐derived cells will strongly influence their use in regenerative medicine; however, this critical feature remains relatively unstudied due to the necessity of humanized mice reconstituted with an immune system autologous to iPSC‐derived cells. Reporting in a recent STEM CELLS Translational Medicine study, researchers led by Christian Beauséjour (Centre de Recherche du CHU Ste‐Justine/Université de Montréal, Montréal, Québec, Canada) employed two distinct humanized mouse models to provide evidence that human immune cell infiltration in skeletal muscle should not be used as the sole marker to predict immunogenicity. Indeed, Benabdallah et al. establish that human iPSC‐derived myogenic progenitors, like primary human myoblasts, are tolerated despite being infiltrated by autologous T cell. Overall, this study provides essential preclinical data supporting the usage of human iPSC‐derived myogenic progenitor cells.