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Lithium-treated Extracellular Vesicles Protect Against Stroke

The findings of a recent STEM CELLS Translational Medicine study from the lab of Thorsten R. Doeppner (University Medical Center Gottingen, Germany) indicate the enhanced therapeutic potential of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) preconditioned with lithium in the treatment of cerebral ischemia (stroke). Haupt et al. report that lithium increases the intravesicular concentrations of selected miRNAs (including miR‐1906, which regulates the toll‐like receptor 4 and familiar proinflammatory signaling cascades) and contributes to enhanced neurological recovery.