You are here

Notch and BMP-mediated Osteoblastogenesis

Stimulation via the canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMP) can induce the osteoblastic differentiation of bone-marrow-derived human mesenchymal stem cells (hMSC); however, the question as to how these two pathways lead to the same phenotypic outcome remains unanswered. Now, in a new STEM CELLS article, researchers led by Yadav Wagley and Kurt D. Hankenson (University of Michigan Medical School, Ann Arbor, MI, USA) explored the transcriptomic profile of differentiating human osteoblasts and established canonical Notch signal itself as a major driver of human osteoblastogenesis with a major regulatory role during BMP stimulation of hMSCs. Overall, these findings demonstrate that BMP signaling results in concomitant activation of Notch signaling and alkaline phosphatase expression, and that blocking Notch signaling abrogates early-phases of human osteoblast differentiation.