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NPC and ICC Delivery for Functional Restoration

A new STEM CELLS Translational Medicine article from Prabhash Dadhich and Khalil N. Bitar (Wake Forest Institute for Regenerative Medicine, Winston‐Salem, NC, USA) describes the development of patient-derived interstitial cells of Cajal (ICCs) and neural progenitor cells (NPCs) as cellular therapy following injection into the pylorus. The team developed a functional ex vivo diseased models of the pylorus and studied ICC/NPC delivery as a treatment for neuromuscular dysfunctionality and confirmed reinstatement and restoration of functionality through detailed quantitative and qualitative analyses. Overall, the authors suggest that the current preliminary study with the ex vivo disease model will prompt the development of next-generation cell therapy for the treatment of gastroparesis.