You are here

Perivascular Stem Cells and Notch Signaling

In a recent STEM CELLS Translational Medicine article, researchers led by Thimios A. Mitsiadis (University of Zurich, Switzerland) reported on the importance of Notch signaling in the interaction between mesenchymal stem cells (MSCs) and their niches. They demonstrate that endothelial cells in dental tissues express all five NOTCH ligands and constitute conserved perivascular niches, which can regulate the activation of NOTCH3-expressing perivascular MSCs. Overall, this fundamental information establishes a new conceptual framework that could be the basis for future research focusing on MSCs-based regenerative approaches.