You are hereMarch 24, 2020
Propagation of Human Prostate Tissue from iPSCs
Culturing cells from prostate cancer biopsies to study mechanisms of disease and discover novel treatments suffers from many difficulties; however, a new study from the laboratory of Rakesh Heer (Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK) has established a new means to grow “mini 3D prostates” in the laboratory. Hepburn et al. provide proof of concept for genetic modifications in this innovative model, which lays the foundations for new preclinical approaches to personalized care that were previously considered a challenging prospect. The team hopes next to develop genetically engineered prostate cancers in a dish that are tailored to the specific genetic profiles of individual patients and determine their responses to a range of drug treatments. For all the exciting details, see STEM CELLS Translational Medicine now!