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Skin Fibroblasts Induce Local Nerve Regeneration

A new STEM CELLS Translational Medicine article from researchers led by Chunmeng Shi and Yu Wang (Army Medical University, Chongqing, China) reports on the activation and reprogramming of fibroblasts into a neural cell-like state following wounding and how their direct contact with local nerves promotes axon regrowth through the ID1/ID3-Itga6 pathway. Chen et al. also established that the transplantation of ID1/ID3 fibroblasts significantly improved local nerve regeneration following wounding. The results of the present study increase our current understanding of the pathophysiology of local nerve injury and may aid the challenge of treating peripheral nerve disorders and peripheral neuropathies in relatively chronic refractory wounds.