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TransSynW - A Web App for Cell Conversion

A new STEM CELLS Translational Medicine article from the lab of Antonio del Sol Mesa (University of Luxembourg, Belvaux, Luxembourg) reports on the TransSynW computational web application, which can identify cell conversion transcription factors for any cell population in single‐cell RNA‐sequencing data. Ribeiro et al. note that TransSynW does not require prior biological information, computer programming, or computational resources from the users. TransSynW also prioritizes pioneer factors among predicted conversion transcription factors to facilitate the chromatin opening process often required for cell conversion and predicts marker genes to assess cell conversion experiments. Overall, the authors establish TransSynW as a fundamental tool to guide the design of novel cell conversion protocols in stem cell research and regenerative medicine.