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Vascularization of Human Brain Organoids

The vascularization of brain organoids may help widen the use of brain organoids to fields in which they have not yet been applied, such as investigating neurovascular interactions on a human platform. To date, multiple studies have aimed to vascularize brain organoids by modifying in vitro culture and in vivo transplantation. In their recent STEM CELLS review article, Takeshi K. Matsui and Ken‐ichiro Kuwako (Shimane University School of Medicine, Izumo, Shimane, Japan) highlight those studies exploring the vascularization of human brain organoids and discuss the future use of microfluidic devices for in vitro vascularization of human brain organoids.