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What’s the Stem Cells Buzz this Week? – Limbal Epithelial Cell Culture, Stem Cell-mediated Tendon Regeneration, Quality-Quantity Stem Cell Culture, and Muscle Stem Cell Regulation via FoxM1!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Amniotic Membrane as a Substrate for Limbal Epithelial Cells

A new review article out of the lab of Amer Sehic (University of Oslo, Norway) discusses the rationale behind employing altered versus unaltered amniotic membrane (AM) as a culture substrate for the ex vivo expansion of the limbal epithelial cells (LECs) used to treat limbal stem cell deficiency (LSCD). Of note, the choice of culture substrate can affect cell phenotype, and Utheim et al. present the case for the use of denuded (i.e., de‐epithelialized) AM or intact AM and the option of crosslinking AM to increase thermal and mechanical stability, optical transparency, and resistance to collagenase digestion. Head over to STEM CELLS Translational Medicine now for what sounds like a highly interesting article.

Guided Stem Cell Fate for Tendon Regeneration

The application of stem cells as a treatment for tendon disorders appears to have a very bright future. A new review article from the lab of Zi Yin (Zhejiang University, China) focuses on the search for bioactive molecules that can potentially induce tenogenesis in adult stem cells. Additionally, Zhang et al. also discuss the molecular regulatory mechanisms of tenogenesis, the various challenges in developing standardized protocols for achieving efficient and reproducible tenogenesis, and future directions for tendon regeneration. See STEM CELLS Translational Medicine now for another excellent review article.

Effect of Quality‐Quantity Culture on Diabetic EPC Function

The low total number and functionality of autologous endothelial progenitor cell (EPC) currently hampers their application in ischemic repair and wound healing in diabetic patients. However, a new approach devised by researchers from the lab of Rica Tanaka (Juntendo University, Tokyo, Japan) may have solved this problem. Tanaka et al. demonstrate that their quality‐quantity culture (QQc) system restored the vasculogenic and wound‐healing efficacy of murine diabetic EPCs following transplantation into a mouse model, suggesting that their approach may significantly improve cell-based treatments for diabetic wounds and other ischemic diseases. For more, see STEM CELLS Translational Medicine now!

FoxM1 Regulation of LncRNAs Enhances the Proliferation and Survival of Muscle Stem Cells

A new research article from the laboratories of Jieping Chen and Yu Hou (Third Military Medical University, Chongqing, China) sought to describe the potential function of the FoxM1 transcription factor in muscle satellite cells (SCs). Previous studies had highlighted a role for FoxM1 in regulating cell proliferation, differentiation, senescence, apoptosis, and tissue homeostasis. The author’s new research suggests that FoxM1 mediates SC proliferation and survival via the regulation of two long noncoding RNAs (lncRNAs): Snhg8 and Gm26917. For more of the details on this novel finding, head on over to STEM CELLS now.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!