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What’s the Stem Cells Buzz this Week? – NSC Regulation, MSC Chondrogenesis, Revealing HSC Heterogeneity, and Fetal Membranes in Regenerative Medicine!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Regulating NSCs via Cdk4 and Insulin-IRS2

Researchers from the labs of Isabel Fariñas (Universidad de Valencia, Spain) and Deborah Burks (CIPF, Valencia, Spain) sought to explore the effects of insulin on adult neural stem cells (NSCs). Chirivella et al. now report that insulin receptor substrate 2 (IRS2) mediates an increase in G1-phase cyclin-dependent kinase 4 (Cdk4) activity and cell cycle progression in response to insulin, and this promotes terminal differentiation of NSCs. Could this data be employed to construct a rational strategy for efficient neuron generation for the treatment of a wide range of disorders? See STEM CELLS now for the answer!

ROR2 Marks MSCs with Enhanced Chondrogenic Potential

Multipotent mesenchymal stem cells (MSCs) represent a mixed population of cells with differing potential; so, how can we tell them apart? New research from the lab of Anthony P Hollander (University of Liverpool, UK) reveals that MSCs expressing high levels of ROR2 (receptor tyrosine kinase like orphan receptor 2) represent a defined population of cells with enhanced cartilage-producing capabilities. Dickinson et al. hope that these findings may aid in the quest to construct a more effective cell therapy for cartilage injuries. See STEM CELLS for all the details.

Revealing HSC Heterogeneity after Infection

A new study from the labs of Adam L MacLean and Michael PH Stumpf (Imperial College London, London, UK) sought to analyze the heterogeneity of the hematopoietic stem cell (HSC) system in response to infection (by Trichinella spiralis) to uncover alterations to 3D niche dynamics and migration patterns. Their STEM CELLS study indicates that infection promotes two differing dynamic HSC strategies (a pattern of revisiting previously explored space and a pattern of exploring new space) that may enable mice to cope better in deteriorating HSC-niche microenvironments following infection.

Reviewing the Application of Fetal Membranes in Regenerative Medicine

A recent review article from Rebecca Lim (Hudson Institute of Medical Research, Victoria, Australia) hopes to tell us the history and the possible future regenerative worth of the fetal membrane of the amniotic sac. While the fetal membrane has found clinical use for over a century, recent studies on the membrane and derived stem and stem-like cells have brought this potentially exciting material back into the spotlight. Head on over to STEM CELLS Translational Medicine to read more about this old, but new potentially exciting resource!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!