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What’s the Stem Cells Buzz this Week? - BM‐MSC-EVs ameliorate GVHD, MS-QC of hESCs, Adult Lung Repair, hMSC Metabolic Changes after Transplants!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Human BM‐MSC‐derived EVs ameliorate GVHD

Human bone marrow mesenchymal stem cell (BM-MSC) therapy for acute graft-versus-host disease (aGVHD) shows great promise; however, the mechanisms at play remain to be fully delineated. Now, researchers from the lab of Yasuo Miura (Kyoto University Hospital/Hiroshima University, Japan) demonstrate that BM-MSC-derived extracellular vesicles (EVs) can recapitulate the therapeutic effects of BM-MSCs and suggest that EVs preserve circulating naive T cells, possibly via the action of multiple miRNAs. See STEM CELLS now for what could represent the first step towards a cell-free therapy for aGVHD.

Mass Spectrometry Quality Control of Cell Cultures

The industrial growth of human stem cells for a wide range of therapeutic applications will require a certain degree of quality control to ensure safety and effectiveness. Researchers from the lab of Aleš Hampl (Masaryk University, Brno, Czech Republic) now establish that intact cell mass spectrometry (MS) represents a robust and straightforward approach for the quality control of human embryonic stem cell (hESC) cultures. Vaňhara et al. demonstrate how MS fingerprints can detect culture adapted and differentiated hESCs even given the lack of morphological and biochemical alterations. See STEM CELLS Translational Medicine now for all the details.

Lung Repair by Adult Lung Cell Transplantation

Given the longstanding therapeutic challenge of repairing injured lungs and the limitations of fetal cell-based therapy, researchers from the lab of Yair Reisner (Weizmann Institute of Science, Rehovot, Israel) have investigated whether adult lungs could offer an alternative source of lung progenitors for transplantation. Krentsis et al. discovered that a single cell suspension derived from adult mouse lungs could repair lung damage in a mouse model, suggesting that the isolation and propagation of adult human lung stem cells may represent an exciting future means to treat human patients. Head over to STEM CELLS Translational Medicine to discover more about this fascinating approach.

Metabolic Changes to hMSC prompt Poor Cell Survival

A new study from the laboratory of Hervé Petite (Université Denis-Diderot, Paris, France sought to analyze the metabolic changes human mesenchymal stem cells (hMSCs) undergo following exogenous administration to discern whether this represents a therapeutic “barrier”. Their new STEM CELLS study suggests that hMSCs do not survive well in vivo due to the failure of their metabolism to adapt to an ischemic environment, an insight that may prompt the introduction of metabolomic support strategies as a means to improve the therapeutic efficacy of hMSCs.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!