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What’s the Stem Cells Buzz this Week? - Corneal Stem/Progenitor Cell Regulation, Progenitor Cell Muscle Healing, Reviewing the Perivascular ECM, and Granulocyte/Macrophage Progenitor Proliferation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Delineating the Regulation of Corneal Stem/Progenitor Cells

Previous studies have indicated a role for the SOX2 and P63 transcription factors in corneal epithelial regeneration, with P63 described as a critical regulator of limbal stem cells (LSCs). New research from the lab of Ruby Shalom‐Feuerstein (Technion ‐ Israel Institute of Technology, Haifa, Israel) now establishes that SOX2 regulates P63 to control corneal epithelial stem/progenitor cell function. Bhattacharya et al. hope that their findings will provide for a better understanding of disease mechanisms involving mutations in SOX2 and P63 and contribute towards novel therapeutic approaches to restore vision. Head over to STEM CELLS now to see all the fine print.

The Role of Muscle Progenitor Cells in Enhanced Muscle Healing

The enhanced regenerative capacity of the so-called “super‐healing” Murphy Roths Large mouse makes it a prime candidate for the study of the molecular and cellular mechanisms at play during tissue regeneration. Researchers from the labs of Aiping Lu and Johnny Huard (The University of Texas Health Science Center at Houston, TX, USA) recently employed this model to demonstrate how the enhanced function of muscle progenitor cells (MPCs) permitted improvements in muscle repair. Tseng et al. also highlighted the importance of elevated levels of antioxidants to muscle repair, suggesting that the modulation of anti-oxidative stress may represent a novel therapy to improve muscle healing after injury, disease, and aging. See STEM CELLS now for all the exciting details.

Reviewing the Role of Endothelial Cell-Extracellular Matrix in Homeostasis and Repair

A concise review from the lab of Ton J. Rabelink (Leiden University Medical Center, The Netherlands) hopes to describe how perivascular extracellular matrix (ECM) can function as a platform for the mechano‐, growth factor-, and angiocrine-signaling required for tissue homeostasis and organ repair. Witjas et al. believe that this information may impact the field of regenerative medicine, for example, when designing artificial matrices or applying decellularized scaffolds from organs. Discover more on this fascinating subject at STEM CELLS Translational Medicine.

Integrin β2 and Granulocyte/Macrophage Progenitor Proliferation

Previous studies from the lab of Ying‐Mei Feng (Capital Medical University, Beijing, China) reported that Integrin β2 loss might skew the differentiation of hematopoietic stem/progenitor cells towards the myeloid lineage. Now, the team returns to demonstrate that Integrin β2 deficiency promotes the proliferation of granulocyte/macrophage progenitors (GMPs) and the production of myeloid cells via FcεRIα/IgE‐induced JNK phosphorylation. For more details on this new study from Zhang et al., make your way over to STEM CELLS now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!