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What’s the Stem Cells Buzz this Week? - ESRP1 and Pluripotency, DNA Damage and iPSCs, Prokineticin and Epicardial Stemness, and Age-Related Clonal Hematopoiesis!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

ESRP1 as a Key Regulator of Human Pluripotency

A recent study from the lab of Yee Sook Cho (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) sought to fully appreciate the link between epithelial splicing regulatory protein 1 (ESRP1) expression and human pluripotency. Interestingly, Kim et al. discovered the specific expression of only specific ESRP1 isoforms in pluripotent stem cells controlled the isoform-specific expression of the cell surface protein CD44. For more on this exciting new finding, see STEM CELLS now!

High Gamma-H2AX Associates with Replication in iPSCs

Researchers from the lab of Deborah A. Hursh (United States Food and Drug Administration, Silver Spring, MD, USA) recently reported that the rapid replication of human induced pluripotent stem cells (iPSCs) leads to the appearance of increased basal levels of gamma-H2AX, a marker of DNA damage. Interestingly, DNA damage is lower in original donor fibroblasts and iPSC-derived mesenchymal stem cells. Vallabhaneni et al. hope that their results, published in STEM CELLS, will aid in the understanding of factors that contribute to the safety of iPSCs in clinical applications.

Prokineticin and Human Epicardial Cell Stemness

Human epicardium‐derived progenitor cells (hEPDCs) may give rise to epicardial adipose tissues and vascular tissues in the developing and injured heart. New research led by Canan G. Nebigil (University of Strasbourg, CNRS (UMR 7242), France) now suggests that the angiogenic hormone Prokineticin controls anti‐adipogenic and pro‐vasculogenic differentiations of hEPDCs via an epigenetic “switch”. Qureshi et al. suggest that their findings may pave the way for innovative new treatments for heart failure; see the full article at STEM CELLS now to find out!

Reviewing Age-Related Clonal Hematopoiesis

A recent review article from Lambert Busque (Hôpital Maisonneuve‐Rosemont, Montréal, Québec, Canada) discusses the recent characterization of clonal hematopoiesis in a large segment of the aging population, a finding that has raised tremendous interest and concern. Studies have documented mutations in genes associated with hematological cancers, and although these individuals maintained blood cell production, a minority will progress to hematologic malignancies. For this reason, the risk factors for progression must be identified, with clonal hematopoiesis offering an opportunity to understand the biology and adaptation mechanisms of aging and mechanisms of malignant transformation. See STEM CELLS for the full story.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!