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What’s the Stem Cells Buzz this Week? - Fibrotic Liver Regeneration, Reviewing Tooth Initiation, Corneal SOX2 Expression via CRISPR, and Epigenetic Regulation of MSC Fate!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

A Novel Accelerator of Fibrotic Liver Regeneration

While Granulocyte‐colony stimulating factor (G‐CSF) can mobilize and enhance the proliferation of hepatic progenitor cells (HPC) to ameliorate impaired liver function, the exact mechanisms at play remain unknown. Now, researchers from the group of Yutaka Inagaki (Tokai University, Kanagawa, Japan) have identified opioid growth factor receptor-like‐1 (OGFRL1) as a novel bone marrow cell‐derived accelerator of fibrotic liver regeneration in response to G‐CSF treatment. Yanagawa et al. hypothesize that the administration of cells overexpressing OGFRL1 may serve as a regenerative therapy for advanced liver fibrosis; discover more at STEM CELLS now!

Cellular and Molecular Mechanisms Regulating Tooth Initiation

A new review article from Anamaria Balic (University of Helsinki, Finland) aims to provide an overview of the molecular and cellular mechanisms that guide the initial stages of tooth development and outline potential obstacles. While studies have unraveled many layers of the molecular regulation of tooth development, regulation of the initial stages of tooth development, as well as the cellular mechanisms that govern tooth development, remain mostly unknown. See STEM CELLS for more.

SOX2 Activation Using CRISPR Activation

Human corneal endothelial cells (hCECs) do not regenerate, thereby representing a problem for those suffering from corneal endothelial diseases. For these reasons, esearchers from the lab of Young Joo Shin (Hallym University College of Medicine, Seoul, Korea) set out circumnavigate this problem. Now, Chang et al. report that CRISPR activation mediated overexpression of SOX2 in the corneal endothelium of Sprague–Dawley rats promoted wound healing and regeneration. Does CRISPR activation hold the key to treating corneal endothelial disease? Head over to STEM CELLS now to discover more!

Ash1l Regulates Mesenchymal Stem Cell Fate Decision

Following the discovery that loss of the Ash1l histone methyltransferase can lead to arthritis with more severe cartilage and bone destruction, researchers from the lab of Ling Ye (Sichuan University, Chengdu, China) sought to document the function of Ash1l in skeletal formation. Reporting in STEM CELLS, Yin et al. now demonstrate a positive correlation between bone mass and the expression of Ash1l, with histone methyltransferase activity playing a significant role. The authors anticipate that their findings will prompt the development of new therapeutic strategies to promote osteogenesis.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!