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What’s the Stem Cells Buzz this Week? - Müller Glia-Derived Progenitor Cells, hPSC Osteogenesis, lncRNA-mediated Differentiation, and MSC in vivo Kinetics!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Deciphering RA-mediated control of MGPCs

Researchers from the laboratory of Andy J. Fischer (Ohio State University, USA) recently employed a chick model system to decipher how retinoic acid (RA)-signaling influences the proliferation and the formation of Müller glia-derived progenitor cells (MGPCs). Their STEM CELLS study suggests that Müller glia of damaged retinas upregulate cellular RA binding proteins (CRABP), leading to the formation of proliferating MGPCs and the enhancement of the neurogenic potential of MGPCs and stem cells in the circumferential marginal zone (CMZ).

Epigenetic Influence on hPSC Osteogenesis

The process by which human pluripotent stem cells (hPSCs) differentiate into bone-forming osteoblasts represents and incompletely understood process. However, researchers from the lab of Nicole I. zur Nieden (University of California Riverside, USA) now suggest that epigenetic patterns at critical regulatory genes (osteocalcin (OCN), PAX7, and TWIST1) can strongly influence lineage derivation and mineralization. See STEM CELLS now for all the details!

Controlling Neural Differentiation via lncRNAs

Rather than osteogenesis, the labs of Guiying Wang and Jiuhong Kang (Tongji University, Shanghai, China) have sought to determine all there is to know about neurogenesis from embryonic stem cells (ESCs)! Their new STEM CELLS study describes how a newly discovered long noncoding RNA (lncRNA-1604) functions as a novel competing endogenous RNA of miR-200c and a regulator of the core transcription factors ZEB1 and ZEB2 during neural differentiation. Sounds like a fantastic study!

Reviewing in vivo Kinetics of MSCs

Researchers from the laboratories of Michael S. Roberts and Haolu Wang (University of Queensland, Australia) believe that mesenchymal stem cells (MSC) therapy optimization may be accelerated via the understanding of MSC distribution in vivo, long-term viability, as well as their biological fate. Their new STEM CELLS Translational Medicine review outlines current knowledge of in vivo kinetics of MSCs, analyses methods employed for MSC detection, discusses the pharmacokinetic modeling of these data, and provides insights on the future development of effective therapeutic strategies using pharmacokinetic modeling.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!