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What’s the Stem Cells Buzz this Week? - miRNA Mimics, Cell Mimicking Microparticles, Stem Cell Therapy for Lung Transplant Dysfunction, and Stem Cell‐derived Photoreceptors!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

microRNA Mimics induce ESC Differentiation

A new study on microRNAs from the laboratory of Maria A. Ciemerych (University of Warsaw, Poland) may have discovered a potent means to direct the differentiation of embryonic stem cells (ESCs). Bem et al. observed that different microRNA expression patterns characterized ESCs with varying differentiation propensities, and subsequently the team demonstrated that the overexpression of microRNA “mimics” affected the phenotype of differentiating ESCs and improved myogenic differentiation. See more details at STEM CELLS.

Cell Mimicking Microparticles in Stem Cell Science

Cell-mimicking microparticles (CMMPs) may provide stem cells with the support they require post-transplantation to improve their regenerative potential. Now, a new review article from the lab of Eric M. Darling (Brown University, Rhode Island, USA) provides a summary of the strengths, weaknesses, and ideal applications of micro/nanoparticle fabrication and an outlook on the future of this technology. See STEM CELLS Translational Medicine for what sounds like a fascinating read!

Safety of Stem Cell Therapy for Obstructive CLAD

Allogeneic mesenchymal stem cell (MSC) therapy may represent an interesting therapeutic option to combat moderate obstructive chronic lung allograft dysfunction in lung transplant recipients. Now, research from the lab of Cesar A. Keller (Mayo Clinic, Jacksonville, Florida, USA) established that the intravenous infusion of bone marrow-derived MSCs is safe and feasible, so warranting more studies to assess effectiveness in the management of acute or chronic graft dysfunction. STEM CELLS Translational Medicine has all the fine print.

Human Stem Cell‐derived Photoreceptor Purification

Robust cell isolation and purification protocols will support future therapies applying stem-cell-derived photoreceptor cells. New research from Jane C. Sowden and Jörn Lakowski (University College London, UK) now describes a novel biomarker combination for the robust fluorescence‐activated cell sorting (FACS) purification of viable human photoreceptors from both human retinae and hPSC-derived organoid cultures. For more details on this promising system, see STEM CELLS now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!