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What’s the Stem Cells Buzz this Week? - P2X7 and Adult Neurogenesis, Perivascular Stem Cell Precursors, Cellular Therapeutics and Clot Formation, and MSC-Based Drug Delivery Review!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Functional roles of P2X7 during adult neurogenesis

New research from the labs of Michael W Weible II (Griffith University, Nathan, Australia) and Ben J. Gu (University of Melbourne, Melbourne, Australia) sought to uncover possible roles of the multifunctional P2X7 receptors in adult neurogenesis. Via the analysis of neural progenitor cells (NPCs) derived from adult murine hippocampal subgranular (SGZ) and cerebral subventricular (SVZ) zones, Leeson et al. report that P2X7 receptors can form transmembrane pores leading to cell death, regulate rates of proliferation via calcium signaling, and function as scavenger receptors in the absence of ATP, allowing NPCs to phagocytose apoptotic NPCs during neurogenesis. See STEM CELLS now for more details.

Perivascular Stem Cell Precursors

While pericytes act as precursors of resident adult stem cells in stromal tissues in vivo, pericytes expanded in vitro display a more extensive multi‐lineage differentiation potential. Val Yianni and Paul T Sharpe (Kings College London, London, UK) sought to discover why this occurs in a recent STEM CELLS study. Overall, their fascinating transcriptomic and epigenomic study suggests that pericyte populations derived from mouse incisors and bone marrow are molecularly obstructed from differentiating down specific lineages in vivo.

Cellular Therapeutics Accelerate Clot Formation

for all the fine print.

Reviewing Mesenchymal Stem Cell-Based Drug Delivery

The clinical potential for mesenchymal stem cell (MSCs)‐based therapies and synthetic biology approaches, in general, continues to build, with more and more of said approaches undergoing evaluation in the clinic. However, a new review from the lab of W. Nathaniel Brennen (Johns Hopkins University School of Medicine, Baltimore, Maryland, USA) hopes to serve as a “sobering reminder” that MSCs display broad biodistribution and poor homing efficiency to most target tissues observed employing current methodologies. Therefore, Krueger et al. suggest that enhanced targeting strategies to potentiate efficient and effective clinical translation of these strategies are much required! To read more on this fascinating area, click your way to STEM CELLS Translational Medicine now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!