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Muscle Stem Cells

DEC Cell Therapy for DMD Treatment

Human dystrophin expressing chimeric cells represent a promising treatment approach for Duchenne muscular dystrophy

Post-translational Protein Modification Regulates Muscle Satellite Cell Function

O‐GlcNAcylation plays a critical role in maintaining satellite cell health and function in both normal and injured skeletal muscle

O‐GlcNAcylation Maintains Satellite Cell Function

O‐GlcNAcylation in satellite cells helps to maintain homeostasis and adjust behavior under normal conditions and during adult regenerative myogenesis

A New Target Identified in the Battle Against Age-related Muscle Loss

A new study suggests 15-hydroxyprostaglandin dehydrogenase inhibition as a means to counteract the loss of muscle function observe during normal aging

Exploring the Immunogenicity of Human iPSC-derived Cells

While transplanted human iPSC-derived skeletal muscle cells become infiltrated by immune cells after transplantation, this does not negatively impact engraftment

Skeletal Muscle Regeneration by Hippo Inhibition

A novel treatment targets the muscle stem cell niche to promote myogenesis, angiogenesis, and neovascularization

MuSC Activation and Regenerative Potential After Denervation

Stem cells within denervated muscle maintain regenerative capabilities comparable to those in uninjured muscle

CEBPβ Promotes MuSC Quiescence

C/EBPβ overexpression induces the expression of quiescence‐associated genes in myoblasts

Dlk1 Regulates CalcR‐mutant MuSC Quiescence

The CalcR‐PKA‐Yap1 axis inhibits Dlk1 expression and Dlk1 loss rescues the impaired quiescent state in CalcR‐mutant MuSCs

Alterations to Silent Chromatin Underlie Loss of Function in Aging Stem Cells

Aging negatively impacts muscle regeneration through altered metabolism, chromatin, transcription factor binding, and gene expression in muscle stem cells

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