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Haematopoetic Stem Cells

Transcription Factor Cooperation Drives Human Hematopoietic Stem and Progenitor Cell Specification

Researchers describe how transcription factor cooperation aids the generation of hemogenic precursors from human fibroblasts via an endothelial intermediate

The Human Intestine as a New Reservoir for Functional Hematopoietic Stem and Progenitor Cells

A report now establishes that intestinal graft-resident HSPCs contribute to long-term multilineage blood chimerism after human intestinal transplantation

Enhancing CRISPR/Cas9 Gene Editing of Human Hematopoietic Stem Cells

A Cas9 variant with cell cycle-specific activity coupled with cell synchronization improves the efficiency of hematopoietic stem cell gene editing

Hematopoietic Stem Cell Sorting: Keeping it Simple with a CD11a and EPCR Combination

A simple combination of two markers may provide a quick and easy means to sort mouse hematopoietic stem cell from blood samples

Enhancing the Clinical Potential of Umbilical Cord Blood on Hematopoietic Recovery

A study highlights an efficient means to expand hematopoietic stem/progenitor cells in non-enriched umbilical cord blood thereby boosting clinical potential

New HSC Rejuvenation Strategy May Improve Bone Marrow Transplantation

Researchers discover that treatment with microvesicles from young MSCs can rejuvenate aged HSCs and potentially improve bone marrow transplantation outcomes

Single-Cell Studies Help to Define Early Human Hematopoiesis

Researchers employ single cell analyses to describe the very earliest stages of the hematopoietic differentiation of human pluripotent stem cells

New Model System Describes the Importance of Smarca5 to Hematopoiesis

Researchers investigate the role of the Smarca5 chromatin remodelling factor in hematopoiesis using a new conditional knockout animal model

It's What's on the Inside That Counts for Newly Identified Human Blood Cells!

RNA-based analysis suggests the existence of additional blood immune cells not identified by the expression of surface markers or morphology

Breathing and Making Blood? – A new Role for the Lungs

A new study now indicates that the lungs contain hematopoietic progenitors and contribute significantly to platelet formation 

 

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