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Cardiac Stem Cells



Novel Reprogramming Approach for Cardiosphere-based Myocardial Regeneration

A new study in a myocardial infarction mouse model demonstrates how a novel reprogramming approach may permit enhanced cardiosphere-based myocardial regeneration

Age-Dependency in Cardiac Progenitor Cell Therapy

Researchers underline the importance of donor age in human cardiac progenitor cell therapy in a mouse model

New Strategy for Enhanced Stem Cell-based Cardiac Repair

A new study suggests that overexpression of SDF1α leads to enhanced stem cell-based cardiac repair of the infarcted heart

Boosting Stem Cell Survival to Enhance Cardiac Therapy

Researchers describe a means to enhance cardiac stem cell survival after transplantation in the hope of enhancing the treatment of myocardial infarction

Producing Praiseworthy Progenitors with Protein!

An improved direct reprogramming strategy using protein transduction enhances the production of cardiac progenitor cells from fibroblasts

Towards Effective Stem Cell Treatment of Ischemia

Purified multipotent cardiovascular progenitors promotes recovery after ischemia, and uncover an miRNA mediated pathway mediating their effect.

The Touchy-Feely Side of Cardiac Cell Therapy

Researchers highlight the importance of cell-to-cell contact in cardiosphere‐derived cell-mediated induction of proliferation in cardiomyocytes. Herein we review the findings and discuss the ramifications.

Improving Cardiac Cell Production through Enhancing Early Mesoderm Formation

Researchers find that Insulin-like growth factor/Insulin-mediated induction of mesodermal differentiation aids the production of cardiac progenitor cells from embryonic stem cells towards a strategy to boost cardiac cell production.


Stromal Progenitor Ligands Promote Cardiac Stem-Progenitor Grafts

Mesenchymal stem cell released factors are shown to potentiate the growth and survival of cardiac stem cells allowing for greater engraftment in the ischaemic mouse heart.

Cell Renewal Demonstrated by Resident Cardiomyocytes

"Mammalian heart renewal by pre-existing cardiomyocytes"

Controversy reigns in the area of adult heart cell regeneration. Until recently it was thought there was no adult regenerative capacity, but even though this dogma has now been abolished, the rate at which it occurs and the source of this de novo regeneration is still debated. Some studies suggest that there is a high level of differentiation of progenitors to cardiomyocytes (Hosoda et al) and their turnover is high (Kaystura et al), while other studies suggest that new cardiomyocytes are made at a very low level (Soonpaa and Field, Bergmann et al and Walsh et al). Additional controversy stems from the question of the source of these cardiomyocytes and therefore the plasticity of the heart; do they come from the division of existing myocytes (Kikuchi et al), progenitors residing in the heart (Beltrami et al) or from exogenous niches, such as the bone marrow (Orlic et al)? To attempt to address these questions, researchers from the laboratory of Richard T. Lee at the Harvard Stem Cell Institute, Cambridge, Massachusetts, USA have used multiple tracking techniques to demonstrate that the genesis of cardiomyocytes indeed occurs at a low rate through the division of pre-existing cardiomyocytes, a phenomenon which is exacerbated by injury (Senyo et al).


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