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Direct Reprogramming

Lin28 Neuronally Reprograms Inner Ear Glia

The loss or damage of auditory neurons can lead to sensorineural hearing loss and deafness, and treatments such as amplification and cochlear implants rely on surviving neurons to convey auditory signals to the brain. Regeneration strategies that focus on endogenous cell therapy may permit the replacement of lost neurons to restore the auditory circuit.

Transdifferentition of Fibroblasts into Osteoblasts Provides Boost for Bone Tissue Engineering

Researchers describe how Insulin‐like growth factor binding protein‐7 can prompt the transdifferentiation of fibroblasts into osteoblasts that can form ectopic bone

Direct Osteoblastic Reprogramming by IGFBP7

Cell therapy in bone tissue engineering has considerable translational potential; however, the limited harvest of osteoblasts and mesenchymal stem cells, and a poor osteogenic potential of isolated patient fibroblasts constrain current approaches.

Human Peripheral Blood Converted Sensory Neurons

While previous reports demonstrated that human sensory neurons could be directly converted from primitive CD34+ hematopoietic cells, the small scale and derivation from less abundant allogenic sources of cord or drug mobilized peripheral blood represented problems.

ProNGF Controls Adult Hippocampal Neurogenesis

To explore the role of proNGF, the precursor of nerve growth factor (NGF), on the biology of adult neural stem cells (NSCs), researchers from the labs of Antonino Cattaneo

Refining and Defining the Optimal Recipe for Astrocytes to Neuron Conversion

Researchers refine a chemical cocktail to four small molecule drugs and define the signaling pathways vital for astrocytes-neuron conversion

Direct Reprogramming from Blood to Brain May Boost Complex Genetic Studies of Disease

A new study suggests that direct reprogramming from blood to brain can boost our understanding of how complex genetic alterations can influence neuro-related diseases and disorders

A Direct Solution to a Schwann cell Problem?

A new study suggests that directly reprogrammed Schwann cells boast a similar regenerative activity to primary Schwann cells derived from patients

3D Scaffolds – The Way Forward for Improved Neural Therapies?

New research finds that directly reprogrammed neurons grown on a 3D growth substrate may represent a new means so boost survival and functionality after transplantation into the brain

Mogrify – Cell Conversion Made Easy?

A new computer program aims to streamline the process of direct reprogramming/transdifferentiation by predicting the reprogramming factors needed for any conversion

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