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Organ-on-Chip Stem Cell Coculture Provides Boost for Study of Motor Neuron Disease

A new study demonstrates how three-dimensional coculture of induced pluripotent stem cell-derived spinal motor neurons enhances both cell maturity and functionality

Small Molecules boost Cpf1-mediated Genome Editing in Pluripotent Stem Cells

Chinese researchers discover of two small molecule compounds that enhance CRISPR-Cpf1-based genome engineering of human pluripotent stem cells

New iPSC-model of Alzheimer's Disease Points to Viable Therapeutic Approaches

Researchers describing a novel induced-pluripotent stem cell model of ApoE4-related Alzheimer's disease highlight potentially exciting new treatment approaches

Housekeeping Matters: How Splicing and Protein Synthesis Regulate Pluripotency and Development

A new Cell study highlights the importance of two generally unappreciated mechanisms, splicing and protein synthesis, to the pluripotent state and the developing embryo

DPPA4 Function in Pluripotent Stem Cells: EBP1 Lends a Hand

A new study from the Knoepfler laboratory reveals EBP1 as a major cofactor that influences the transcriptional activity of DPPA4 in pluripotent cells

Another Step towards the Fully Synthetic Culture of Human Pluripotent Stem Cells

A new study takes the field further towards the industrial-scale culture and safe and cost-effective clinical application of human pluripotent stem cells

Laying Bare the Molecular Mechanisms behind Mitochondrial Dynamics in Pluripotent Stem Cells

Researchers studying the molecular mechanisms that control mitochondrial dynamics in pluripotent cells discover a role for the apoptosis-related protein MCL-1

Myoediting: Towards a CRISPR/Cas9-based Treatment for DMD-associated Dilated Cardiomyopathy

Researchers demonstrate how CRISPR/Cas9-mediated exon skipping, or myoediting, may rescue dystrophin function in a majority of Duchenne muscular dystrophy patients

Zeb2-NAT lncRNA: Breaking Down Age-associated Reprogramming Barriers

A new study identifies a long non-coding RNA as an important barrier impeding the reprogramming of cells derived from old patients

Osteoblast Differentiation Study Recommends Choosing your Stem Cell Wisely!

A new study suggests that DNA methylation analysis of select gene promoters can identify the optimal pluripotent stem cell for bone repair strategies

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