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ESCs/iPSCs

BRD4-mediated Regulation of Pluripotency

A new review discusses the central role of BRD4 in stem cell identity and potential applications of BRD4 inhibitors in stem cell-based therapeutics

Overcoming Reprogramming Induced Senescence

A newly discovered mechanism overrides reprogramming-induced senescence, thereby increasing the number of cells amenable to becoming iPSCs

ROS Levels Control PSC Proliferation

Maintaining physiological levels of ROS is essential for proliferation and accurate DNA synthesis in pluripotent stem cells

Fighting Fibrosis with iPSC-derived Macrophages

Researchers demonstrate the ability to efficiently derive macrophages from human iPSCs with the ability to improve liver fibrosis in a mouse xenograft model

Complex Disease Models from 3D Brain Organoids

A new review article stresses the importance of implementing complex 3D brain organoids derived from human induced pluripotent stem cells

New Study Describes the Formation of Embryo-like Entities from Pluripotent Stem Cells

An engineered morphogen signaling center within an embryonic stem cell aggregate supports the development of “embryoids” that exhibit germ layer development

Trpv4 Regulates iPSC Chondrogenesis

An improved understanding of the role of TRPV4 in chondrogenesis may provide insight into the development of new therapeutic approaches

Developing Stem Cell Therapies for Diabetes

A new article discusses the potential of stem cell-derived pancreatic progenitors and matured insulin-producing cells to treat diabetes

SARS-CoV-2, PSCs, and Organoids - A Review

A new review discusses the use of human pluripotent stem cell-derived cells and organoids in severe acute respiratory syndrome coronavirus 2 research

iBlastoids – The Future of Human Blastocyst Research?

New research reports on "iBlastoids" - blastocyst-like structures formed from iPSCs that model several aspects of human blastocyst biology

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