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ESCs/iPSCs

iPSC-based Small Molecule Screening Reveals Possible Dysferlinopathy Treatment Approach

A new study combines skeletal myocyte differentiation of mutation-carrying hiPSCs with drug screen to detect small molecules that boost dysferlin levels

Engineered hiPSC-CMs for Action Potential Assessments

While genetically encoded fluorescent voltage indicators can report on action potentials in human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs), the transfection process presents several drawbacks. To solve this problem, researchers from the laboratory of Deborah K.

Functional APC Required for ESC Self-renewal

To study the role of Adenomatous polyposis coli (APC), a negative regulator of Wnt/β‐catenin signaling, in human embryonic stem cells (ESCs), researchers from the lab of Dalit Ben‐Yosef

Tracking Pluripotent Stem Cells Through the Cell Cycle

FUCCI technology tracks cell division in primed hPSCs to highlight the importance of distinct signaling pathways in regulation of developmental potential

Mouse Embryonic Stem Cell Study Highlights the Factors Controlling the Totipotent State

Researchers combine the efficient formation of 2C-like cells from mESC cultures with CRISPR/Cas9 to identify regulators linked to the totipotent state

New Study Highlights Proper Metabolic Reprogramming in iPSC Generation

A study compares metabolic profile of iPSCs generated under atmospheric or physiological oxygen levels and evaluates their response to elevated oxygen levels

β-Cell Mass Formation in Stem Cell-Derived Implants

A recent study from the lab of Daniel G. Pipeleers (Brussels Free University, Belgium) reported on ex vivo device‐encapsulated human embryonic stem cell‐derived pancreatic endoderm implants in mice that established a metabolically adequate functional β‐cell mass. Now, Robert et al.

Lack of Aicda-mediated Suppression of Fgf/Erk Signaling Inhibits Naïve Pluripotency

A new study reports that while stable reprogramming can occur without the presence of Aicda, resultant mouse iPSCs fail to achieve naïve pluripotency 

Roles of SMYD2 in Mesendoderm Commitment of hESCs

A recent article from the laboratory of Huang‐Tian Yang (University of Chinese Academy of Sciences, Shanghai, China) explored

Epigenetics and Pluripotent States: A Review

There exist various pluripotent states along with early embryonic development in mammals: from totipotency to naïve pluripotency to primed pluripotency. While these pluripotent stem cell populations can both self-renew and differentiate into cells representative of the three germ layers, studies have not made it clear that each cell types displays a unique epigenetic profile.

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