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ESCs/iPSCs

Gene-modified Organoids Aid the Development of Retinal Degenerative Disease Therapies

Studies of NRL expression in retinal organoids may lead to the development of efficient transplantation therapies for retinal degenerative diseases

In vivo Analysis of Friedreich Ataxia iPSC‐derived Neurons

Researchers explore the transplantation of human iPSC-derived DRG sensory neurons into adult rodents as a possible treatment for peripheral neuropathies

Characterizing Photoreceptors in Human iPSC-ROs

Researchers systemically describe the progressive maturation of characteristic ionic components in photoreceptor‐like cells from retinal organoids

High Density Bioprocessing of hPSCs

Instrumented stirred tank bioreactor technology and in silico process modeling may overcome substantial hPSC‐specific hurdles and promote their mass production

iPSC-derived Disease Model Highlights Potential Treatment for Autoinflammatory Disorders

Histone deacetylase inhibitor treatment may represent a potent means to ameliorate the overproduction of inflammatory chemokines in Nakajo‐Nishimura syndrome

Can Newly Identified Transcription Factors Improve iPSC Reprogramming?

Researchers identify factors that may improve the reprogramming process by studying induced pluripotent stem cells generated from Parkinson’s disease patients

Stem Cell-derived CAR‐Natural Killer Cells

A new review discusses the differentiation of iPSCs toward HSC and NK cells displaying chimeric antigen receptors for the treatment of oncological malignancies

Photoreceptor Precursor Transplantation into the Degenerated Retina

Researchers thoroughly assess light responses following transplantation of PSC‐derived cone photoreceptors in a mouse model of photoreceptor dystrophy

GlcSph in GD-iPSC-derived Neurons Deregulates Lysosomes

Elevated glucosylsphingosine levels activate mTORC1 to interfere with normal lysosomal biogenesis and autophagy in iPSC-derived neurons

Induced DNA Repair Generates Genetically Stable iPSCs

CYCLIND1 mRNA transfection helps to repair DNA during reprogramming to pluripotency, resulting in a genetically stable footprint in human iPSCs

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