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ESCs/iPSCs

iPSC-based Treatments for Sensorineural Hearing Loss

A new review highlights the significant achievements and challenges associated with iPSC‐based otic cell modeling

iPSC-derived Organoids Support the Study of Alveolar Cell Differentiation and Function

A new study confirms that alveolar type I cells present in induced pluripotent stem cell‐derived alveolar organoids closely resemble primary alveolar cells

Engineering, β‐cell function, and Diabetes

In vitro models of human β‐cells and insulin secretion as powerful tools to study diabetes

CRISPR Editing of GLI1 in Human ESCs

Reduced GLI1 expression in ESCs by gene-editing leads to differentiation defects

IGFBPs Enable IGF1-mediated Retina Formation

IGFBPs enable IGF1 function during the differentiation of pluripotent stem cells into retinal organoids

ERG1-AKT Control Cardiomyocyte Fate

Researchers describe a novel role of ERG1 in the differentiation process of cardiomyocytes

iPSCs and Advanced Screening Support Drug Discovery for Atrial Fibrillation

Advanced in vitro drug screening platform may significantly accelerate the identification of novel drugs for the treatment of atrial fibrillation

DHODH Inhibition –Ensuring the Safety of Pluripotent Stem Cell-based Regenerative Approaches

A new study provides evidence for the utility of DHODH inhibitors such as brequinar in the development of safe and effective PSC‐based therapies

Lineage‐specific Induction of Gut Tube Endodermal Cells

RPD is highlighted as a promising tool for efficient optimization of pluripotent stem cell differentiation protocols

Influence of NRL Loss on hESC-derived Retinal Organoids

A new study describes a powerful means to generate enriched populations of cone photoreceptor cells in vitro

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