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Top Ten Articles on the Biology of Embryonic and Induced Pluripotent Stem Cells

Protocols to differentiate and examine embryonic stem cells have improved steadily over the past years, and have given biologists incredible insight into lineage commitment and development. Then the Nobel-prize winning development of induced pluripotent stem cells (iPSCs) from adult cell sources completely changed the field of stem cell biology. With the ability to create and study iPSC lines and their lineage-specific derivatives from patients with known diseases and genotypes, the use of this technology has exploded. In the current issue we present our ten top downloaded manuscripts from Stem Cells in 2014-2015, that focus on the biology of embryonic and induced pluripotent stem cells.

Concise Review: Generation of Neurons From Somatic Cells of Healthy Individuals and Neurological Patients Through Induced Pluripotency or Direct Conversion
Iván Velasco, Patricia Salazar, Alessandra Giorgetti, Verónica Ramos-Mejía, Julio Castaño, Damià Romero-Moya and Pablo Menendez

Modeling Human Retinal Development with Patient-Specific Induced Pluripotent Stem Cells Reveals Multiple Roles for Visual System Homeobox 2
M. Joseph Phillips, Enio T. Perez, Jessica M. Martin, Samantha T. Reshel, Kyle A. Wallace, Elizabeth E. Capowski, Ruchira Singh, Lynda S. Wright, Eric M. Clark, Patrick M. Barney, Ron Stewart, Sarah J. Dickerson, Michael J. Miller, E. Ferda Percin, James A. Thomson and David M. Gamm

Concise Review: A Population Shift View of Cellular Reprogramming
Antonio del Sol and Noel J. Buckley

Retinoic Acid Suppresses the Canonical Wnt Signaling Pathway in Embryonic Stem Cells and Activates the Noncanonical Wnt Signaling Pathway
Kwame Osei-Sarfo and Lorraine J. Gudas

Pluripotent Stem Cells Derived From Mouse Primordial Germ Cells by Small Molecule Compounds
Tohru Kimura, Yoshiaki Kaga, Yoichi Sekita, Keita Fujikawa, Tsunetoshi Nakatani, Mika Odamoto, Soichiro Funaki, Masahito Ikawa, Kuniya Abe and Toru Nakano

Live Fluorescent RNA-Based Detection of Pluripotency Gene Expression in Embryonic and Induced Pluripotent Stem Cells of Different Species
Harald Lahm, Stefanie Doppler, Martina Dreßen, Astrid Werner, Klaudia Adamczyk, Dominic Schrambke, Thomas Brade, Karl-Ludwig Laugwitz, Marcus-André Deutsch, Matthias Schiemann, Rüdiger Lange, Alessandra Moretti and Markus Krane

TET2 Deficiency Inhibits Mesoderm and Hematopoietic Differentiation in Human Embryonic Stem Cells
Thierry Langlois, Barbara da Costa Reis Monte-Mor, Gaëlle Lenglet, Nathalie Droin, Caroline Marty, Jean-Pierre Le Couédic, Carole Almire, Nathalie Auger, Thomas Mercher, François Delhommeau, Jesper Christensen, Kristian Helin, Najet Debili, François Fuks, Olivier A. Bernard, Eric Solary, William Vainchenker and Isabelle Plo

Gremlin 2 Promotes Differentiation of Embryonic Stem Cells to Atrial Fate by Activation of the JNK Signaling Pathway
Vineeta Tanwar, Jeffery B. Bylund, Jianyong Hu, Jingbo Yan, Joel M. Walthall, Amrita Mukherjee, William H. Heaton, Wen-Der Wang, Franck Potet, Meena Rai, Sabina Kupershmidt, Ela W. Knapik and Antonis K. Hatzopoulos

PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology
Zoltan Simandi, Erik Czipa, Attila Horvath, Aron Koszeghy, Csilla Bordas, Szilárd Póliska, István Juhász, László Imre, Gábor Szabó, Balazs Dezso, Endre Barta, Sascha Sauer, Katalin Karolyi, Ilona Kovacs, Gábor Hutóczki, László Bognár, Álmos Klekner, Peter Szucs, Bálint L. Bálint and Laszlo Nagy

Differentiation of Human Induced Pluripotent Stem Cells into Brown and White Adipocytes: Role of Pax3
Tala Mohsen-Kanson, Anne-Laure Hafner, Brigitte Wdziekonski, Yasuhiro Takashima, Phi Villageois, Audrey Carrière, Maria Svensson, Claude Bagnis, Bérengère Chignon-Sicard, Per-Arne Svensson, Louis Casteilla, Austin Smith and Christian Dani